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Women's Health

Pitches Trial

Principal Investigator - Miss K McIntyre

Intrahepatic Cholestasis of pregnancy (ICP) or obstetric cholestasis (OC) is a liver disorder which occurs during pregnancy. It affects 1 in 150 pregnancies each year in the UK.  At the moment, not all women in the UK receive the same treatment for ICP; some are prescribed a medicine called UDCA and some are not. This study is to see whether or not UDCA helps to protect babies.  At the end of the study, we hope to be able to give clear and definite guidance for doctors treating this condition.

Stoppit-2

Principal Investigator - Mr J Ford

This study aims to determine whether the Arabin cervical pessary prevents preterm birth in women with a twin pregnancy and a short cervix.  Babies born prematurely have increased risk of health problems and are more likely to require admission to the neonatal unit. 


Gem3

Principal Investigator - Miss R Thompson

A clinical trial looking to see if a combination of drugs called methotrexate and gefitinib can help with the treatment of ectopic pregnancy without the need for an operation. 


Phoenix

Principal Investigator - Miss K McIntyre

To determine whether delivery in women with pre-eclampsia between 34+0 and 36+6 weeks of gestation reduces maternal complications without short and long term detriment to the infant compared to expectant management and delivery at 37 weeks of gestation.

Peacock

Principal Investigator - Miss K McIntyre

(Nested study of PHOENIX) – via a blood test looking at prognostic indicators of severe disease in women with late preterm pre-eclampsia to guide decision making on timing of delivery. This may be a useful test to help doctors decide which women and their babies are more at risk of becoming unwell.

Phoebe

Principal Investigator - Miss K McIntyre

Chronic pelvic pain (CPP) affects over 1 million women in the UK. Evidence based treatments for CPP are limited and management is often unsatisfactory, as many as half of the women with CPP, no cause can be found. This study aims to look at the effectiveness of gabapentin for the management of CPP as it has been used safely and successfully to treat other pain conditions.


Eligible women can take part in the nested studies even if they decline the main Phoenix study.

Gapp2

Principal Investigator - Mr A Swaminathan

Chronic pelvic pain (CPP) affects over 1 million women in the UK. Evidence based treatments for CPP are limited and management is often unsatisfactory, as many as half of the women with CPP, no cause can be found. This study aims to look at the effectiveness of gabapentin for the management of CPP as it has been used safely and successfully to treat other pain conditions.

Rapid

Principal Investigator - Miss S Pinto

The aim of this study is to develop better and safer ways of detecting problems in pregnancy. Research has shown that it may be possible to use a simple blood test taken from the mother early in pregnancy to gather information about the health of the baby and predict certain complications of pregnancy. We will do this by testing the baby’s genes and other substances in the maternal blood. Using new blood tests we are able to identify the baby’s sex, blood group (including rhesus D status) and some genetic conditions and chromosomal problems such as Down’s syndrome. We may also to be able to use these new blood tests to predict complications of pregnancy such as pregnancy-induced raised blood pressure (pre-eclampsia) or poor growth of the baby. 


Futures Initiative

Principal Investigator - Mrs J Brown

The purpose of tis study is to collect blood samples from 3000 healthy individuals over a period of five years. Volunteers will be asked to donate 18mls of blood which will be used for analysis of DNA and plasma. This will be used to establish a database to help identify individuals to take part in future phase 1 clinical trials.


MiQuit

Principal Investigator - Mrs J Brown

RCT and meta-analysis testing effectiveness and cost-effectiveness of a tailored text message programme (MiQuit) for smoking cessation in pregnancy.

Commencing January 2018


PREP

Principal Investigator - Miss R Sawyer

To assess long-term (end of pregnancy) efficacy of electronic cigarettes (EC) compared to efficacy of nicotine transdermal patches when used to help pregnant smokers stop smoking.

Commencing January 2018

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